Jump to main content
Jump to site search

Issue 6, 2017
Previous Article Next Article

Photolysis and cellular toxicities of the organic ultraviolet filter chemical octyl methoxycinnamate and its photoproducts

Author affiliations

Abstract

Organic ultraviolet filter chemicals (UVFCs) are the active ingredients used in many sunscreens to protect the skin from UV light; these chemicals have been detected in numerous aquatic environments leading to concerns about how they might affect aquatic organisms and humans. One commonly used organic UVFC is octyl methoxycinnamate (OMC), better known by its commercial name, octinoxate. Upon exposure to UV light, OMC degrades rapidly, forming numerous photoproducts, some of which have been previously identified. In this study, we isolated and completely characterized the major products of OMC photolysis, including the two major stable OMC cyclodimers. One of these cyclodimers is a δ-truxinate, resulting from a head-to-head dimerization of two OMC molecules, and the other cyclodimer is an α-truxillate, resulting from a head-to-tail dimerization of two OMC molecules. Additionally, the cellular toxicities of the individual photoproducts were determined; it was found that the parent UVFC, OMC, 4-methoxybenzaldehyde, and two cyclodimers are significantly toxic to cells. The photoproduct 2-ethylhexanol is not cytotoxic, demonstrating that different components of OMC photolysate contribute differently to its cellular toxicity. This study thus provides an enhanced understanding of OMC photolysis and gives toxicity data that can be used to better evaluate OMC as a sunscreen agent.

Graphical abstract: Photolysis and cellular toxicities of the organic ultraviolet filter chemical octyl methoxycinnamate and its photoproducts

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Feb 2017, accepted on 11 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7EM00059F
Citation: Environ. Sci.: Processes Impacts, 2017,19, 851-860
  •   Request permissions

    Photolysis and cellular toxicities of the organic ultraviolet filter chemical octyl methoxycinnamate and its photoproducts

    H. V. Stein, C. J. Berg, J. N. Maung, L. E. O'Connor, A. E. Pagano, L. A. MacManus-Spencer and M. G. Paulick, Environ. Sci.: Processes Impacts, 2017, 19, 851
    DOI: 10.1039/C7EM00059F

Search articles by author

Spotlight

Advertisements