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Three-in-one type fluorescent sensor based on pyrene pyridoxal cascade for the selective detection of Zn(II), hydrogen phosphate and cysteine

Abstract

A novel fluorescent receptor L was synthesized by Schiff base condensation of 1-pyrenemethylamine with vitamin B6 cofactor pyridoxal. Receptor L is highly selective and sensitive towards Zn2+ ions among the other tested metal ions. Upon interaction with Zn2+, the receptor L showed a distinct fluorescence enhancement at 485 nm due to the excimer formation leading to the fluorescent colour change from blue to bluish-green. Subsequently, when the in-situ generated ZnL2 complex was interacted with various anions and amino acids, the addition of H2PO4- and cysteine retrieved the fluorescence of the receptor L due to the demetalation of Zn2+ from the ZnL2 complex. Accordingly, the receptor L was developed for the highly selective, specific and sensitive detection of three important bioactive analytes, i.e., Zn2+, H2PO4- and cysteine with the detection limit down to 2.3×10-6 M, 2.18×10-7 M and 1.59×10-7 M, respectively. Additionally, the receptor L was applied for the detection of intracellular Zn2+ ions in live HeLa cells.

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Publication details

The article was received on 09 Nov 2017, accepted on 30 Nov 2017 and first published on 30 Nov 2017


Article type: Paper
DOI: 10.1039/C7DT04234E
Citation: Dalton Trans., 2017, Accepted Manuscript
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    Three-in-one type fluorescent sensor based on pyrene pyridoxal cascade for the selective detection of Zn(II), hydrogen phosphate and cysteine

    Y. Upadhyay, A. thangaraj, L. T. Babu, P. Paira, G. Crisponi, A. K. SK, R. Kumar and S. K. Sahoo, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT04234E

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