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High adjuvant activity of layered double hydroxides nanoparticles and nanosheets in anti-tumour vaccine formulations

Abstract

Effective adjuvants are very important in development of new generation anti-tumour vaccine formulations. In this study, two layered double hydroxide (LDH) nanomaterial forms, i.e. nanoparticles (NPs) and nanosheets (NSs), were synthesised and examined as adjuvants to provoke the immune responses for anti-tumour purpose. Immunogen ovalbumin (OVA) delivered by both nanomaterials induced much stronger humoral and cell-medicated immune responses, together with an immune stimulant (TLR9 ligand CpG), as evidenced by higher levels of IgG1, IgG2a and interferon-γ. In comparison, LDH NSs showed higher activity to promote specific antibody response than LDH NPs but with a similar cell-mediated immune response. The mice immunised with OVA-CpG vaccines formulated with both nanomaterials showed stronger inhibition of the inoculated tumour growth and had a longer survival. Altogether, these data indicate that LDH NPs and NSs can be used as potential nanoadjuvants for efficient protein-based anti-tumour vaccines.

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Publication details

The article was received on 04 Oct 2017, accepted on 07 Nov 2017 and first published on 08 Nov 2017


Article type: Paper
DOI: 10.1039/C7DT03725B
Citation: Dalton Trans., 2017, Accepted Manuscript
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    High adjuvant activity of layered double hydroxides nanoparticles and nanosheets in anti-tumour vaccine formulations

    S. Yan, W. Gu, B. Zhang, B. Rolfe and Z. P. Xu, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT03725B

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