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ROS-mediated Carbon Monoxide and Drug Release from Drug-conjugated Carboxyboranes

Abstract

Elevated levels of reactive oxygen species (ROS) are associated with several detrimental diseases. Therefore, using this condition for selective treatments could be a great advantage in fighting these disorders. Here, we present amine carboxyboranes as a class of molecules for therapeutic CO gas generation and for delivering drug molecules in the presence of ROS. Our findings indicate amine carboxyboranes to be very slow CO releaser at physiological pH and temperature without any inducers but generate CO faster when reacted with a non-radical ROS (H2O2). Furthermore, a radical ROS (•OH) dramatically expedites production of CO from amine carboxyboranes. Decomposition profile shows the release of the amine group during decarbonylation process from drug-conjugated carboxyborane. This suggests that carboxyborane moiety can be a useful tool for delivery of amine containing drugs to disease sites which display abundant ROS level.

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Publication details

The article was received on 22 Sep 2017, accepted on 30 Nov 2017 and first published on 30 Nov 2017


Article type: Paper
DOI: 10.1039/C7DT03581K
Citation: Dalton Trans., 2017, Accepted Manuscript
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    ROS-mediated Carbon Monoxide and Drug Release from Drug-conjugated Carboxyboranes

    T. I. Ayudhya, P. J. Pellechia and N. N. Dingra, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT03581K

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