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Nanoparticles of Metal-Organic Cages Designed to Encapsulate Platinum-Based Anticancer Agents

Abstract

We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(IV) prodrug of cisplatin is developed for the encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer

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Publication details

The article was received on 20 Sep 2017, accepted on 07 Dec 2017 and first published on 07 Dec 2017


Article type: Communication
DOI: 10.1039/C7DT03537C
Citation: Dalton Trans., 2017, Accepted Manuscript
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    Nanoparticles of Metal-Organic Cages Designed to Encapsulate Platinum-Based Anticancer Agents

    Y. Zheng, J. T. Shelley, Z. Yue, H. Wang, M. Stilgenbauer, M. Gao, D. Bowers and F. Nielsen, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT03537C

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