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The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(II) and iron(II) complexes and their superoxide dismutase-like activity studies

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Abstract

Bio-inspired manganese [Mn(N5Py)(H2O)(CH3OH)](ClO4)2 (1) and iron [Fe(N5Py)(H2O)(ClO4)]ClO4 (2) complexes derived from a pentadentate ligand (N5Py = 2,6-bis((E)-1-phenyl-2-(pyridin-2-ylmethylene)hydrazinyl)pyridine) framework containing a N5 binding motif were synthesized and characterized using different spectroscopic methods. The molecular structures of complexes 1 and 2 were determined by X-ray crystallography. These complexes were found to be stable under physiological conditions and exhibited an excellent superoxide dismutase (SOD) activity. The SOD activity was determined by a xanthine–xanthine oxidase–nitro blue tetrazolium assay and the IC50 values were determined to be 1.53 and 2.09 μM, respectively.

Graphical abstract: The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(ii) and iron(ii) complexes and their superoxide dismutase-like activity studies

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Publication details

The article was received on 04 Sep 2017, accepted on 22 Sep 2017 and first published on 25 Sep 2017


Article type: Paper
DOI: 10.1039/C7DT03278A
Citation: Dalton Trans., 2017, Advance Article
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    The design of synthetic superoxide dismutase mimetics: seven-coordinate water soluble manganese(II) and iron(II) complexes and their superoxide dismutase-like activity studies

    O. Singh, N. Tyagi, M. M. Olmstead and K. Ghosh, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT03278A

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