Jump to main content
Jump to site search


Synthesis, characterization, and anticancer activity of two mixed ligand copper(II) complexes by regulating the VEGF/VEGFR2 signaling pathway

Author affiliations

Abstract

The single crystals of two novel mixed-ligand copper(II)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.

Graphical abstract: Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Sep 2017, accepted on 01 Nov 2017 and first published on 02 Nov 2017


Article type: Paper
DOI: 10.1039/C7DT03242K
Citation: Dalton Trans., 2017, Advance Article
  •   Request permissions

    Synthesis, characterization, and anticancer activity of two mixed ligand copper(II) complexes by regulating the VEGF/VEGFR2 signaling pathway

    X. Qin, Y. Wang, X. Yang, J. Liang, J. Liu and Z. Luo, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT03242K

Search articles by author

Spotlight

Advertisements