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Issue 48, 2017
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Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines

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Abstract

A series of ferrocenyl and ruthenocenyl conjugates with colchicine bearing a 1,2,3-triazole moiety were synthesized and their anticancer properties were evaluated. We found that the most potent metallocenyl derivatives Rc4 and Rc5 are 6–7 times more cytotoxic toward HepG2 cells, while Fc4 and Fc5 are two times more cytotoxic toward HCT116 cells as colchicine. We also found that compounds Fc4, Fc5, Rc1 and Rc3–Rc5 are able to induce apoptosis, while compound Fc2 arrests mitosis.

Graphical abstract: Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines

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Publication details

The article was received on 31 Aug 2017, accepted on 20 Nov 2017 and first published on 20 Nov 2017


Article type: Paper
DOI: 10.1039/C7DT03229C
Citation: Dalton Trans., 2017,46, 17041-17052
  • Open access: Creative Commons BY-NC license
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    Colchicine metallocenyl bioconjugates showing high antiproliferative activities against cancer cell lines

    K. Kowalczyk, A. Błauż, W. M. Ciszewski, A. Wieczorek, B. Rychlik and D. Plażuk, Dalton Trans., 2017, 46, 17041
    DOI: 10.1039/C7DT03229C

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