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Issue 36, 2017
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Gold-catalyzed domino cyclization–alkynylation reactions with EBX reagents: new insights into the reaction mechanism

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Abstract

Gold-catalyzed domino processes constitute a useful alternative to C–H functionalization for the synthesis of functionalized (hetero)arenes. Herein, we report computational studies on the gold-catalyzed cyclization alkynylation of keto-allenes with ethynylbenziodoxole (EBX) reagents, which identified a gold(I) picolinate complex as the active catalyst, giving the first mechanistic insights into this transformation.

Graphical abstract: Gold-catalyzed domino cyclization–alkynylation reactions with EBX reagents: new insights into the reaction mechanism

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Publication details

The article was received on 25 Aug 2017, accepted on 28 Aug 2017 and first published on 06 Sep 2017


Article type: Paper
DOI: 10.1039/C7DT03154H
Citation: Dalton Trans., 2017,46, 12257-12262
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    Gold-catalyzed domino cyclization–alkynylation reactions with EBX reagents: new insights into the reaction mechanism

    H. Ghari, Y. Li, R. Roohzadeh, P. Caramenti, J. Waser and A. Ariafard, Dalton Trans., 2017, 46, 12257
    DOI: 10.1039/C7DT03154H

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