Jump to main content
Jump to site search


Towards an MMP-2-activated molecular agent for cancer imaging

Abstract

Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Aug 2017, accepted on 04 Dec 2017 and first published on 04 Dec 2017


Article type: Paper
DOI: 10.1039/C7DT03108D
Citation: Dalton Trans., 2017, Accepted Manuscript
  •   Request permissions

    Towards an MMP-2-activated molecular agent for cancer imaging

    S. Cowell, L. S. Carroll, I. Lavdas, E. O. Aboagye and R. Vilar, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT03108D

Search articles by author

Spotlight

Advertisements