Jump to main content
Jump to site search


A novel phosphorescent iridium(III) complex bearing donor-acceptor-type o−carboranylated ligand for endocellular hypoxia imaging

Abstract

Structure–property relationship of carborane–embedded cationic iridium(III) complexes was investigated in this work, especially with donor-acceptor-type ligands. Firstly, an efficient synthetic approach for the new donor-acceptor-type ligands (2 and 4 ) was developed. By using these ligands, novel iridium(III) complexes II and IV were prepared. Complex IV shows about 92 nm red-shift in solution (ФP = 0.13 in ethanol), and the emission color has an obvious change from green to red when compared with the Model complex. In addition, the photophysical characters of complex IV are quite sensitive to oxygen level in living cells, based on which endocellular hypoxia imaging of complex IV has been realized by the phosphorescence lifetime imaging microscopy (PLIM) technology. Besides experimental studies, density functional theory (DFT) and time dependent DFT (TD–DFT) calculations have been successfully applied to investigate the excited–state electronic structures of carborane-modified iridium complexes.

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Aug 2017, accepted on 14 Sep 2017 and first published on 14 Sep 2017


Article type: Paper
DOI: 10.1039/C7DT03097E
Citation: Dalton Trans., 2017, Accepted Manuscript
  •   Request permissions

    A novel phosphorescent iridium(III) complex bearing donor-acceptor-type o−carboranylated ligand for endocellular hypoxia imaging

    X. Li, Y. Yin, P. Gao, W. Li, H. Yan, C. Lu and Q. Zhao, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT03097E

Search articles by author

Spotlight

Advertisements