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Dinuclear nitrido-bridged ruthenium complexes bearing diimine ligands

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Abstract

Reactions of K3[Ru2NCl8(H2O)2] with 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (dmbpy), and 4,4′-dimethoxy-2,2′-bipyridine (dmobpy) yielded the nitrido-bridged dinuclear complexes [Ru2N(L)2Cl5(DMF)] where L = bpy (1), dmbpy (2), and dmobpy (3). The crystal structures of these complexes reveal a linear Ru–N–Ru moiety with each ruthenium center bearing a bidentate diimine ligand. The complexes were further characterized by NMR, IR, and UV-vis spectroscopic methods and cyclic voltammetry. Because the compounds bear some structural similarities with the mitochondrial calcium uptake inhibitor Ru360, the ability of these complexes to act in this capacity was evaluated. The results demonstrate that 1–3 all fail to block mitochondrial calcium uptake, revealing new facets of the structure–activity relationships for ruthenium-based mitochondrial calcium uptake inhibitors.

Graphical abstract: Dinuclear nitrido-bridged ruthenium complexes bearing diimine ligands

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Publication details

The article was received on 19 Aug 2017, accepted on 02 Oct 2017 and first published on 10 Oct 2017


Article type: Paper
DOI: 10.1039/C7DT03085A
Citation: Dalton Trans., 2017, Advance Article
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    Dinuclear nitrido-bridged ruthenium complexes bearing diimine ligands

    J. Urgiles, S. R. Nathan, S. N. MacMillan and J. J. Wilson, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT03085A

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