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Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier

Abstract

In this work, we have discussed for the first time the elaboration of nanohybrid materials intended for drug delivery systems, based on titanate nanotubes (TiONts) which are coated by chitosan polymer (CT). Chitosan has been used to enhance the biocompatibility of hydrothermally synthesized nanotubes in biological medium in order to substitute the polyethylene glycol (PEG), generally used for biocompatibility purpose. CT grafting was carried out using two different approaches; the first was made by a covalent bond using two intermediate molecules and the second is based on electrostatic interactions between CT and TiONts. It was proved that the type of elaborated bond on the surface of TiONts influence the colloidal stability of elaborated nanohybrids which has been studied in different media. A detailed comparison between these two approaches was carried by XPS and TGA-SM techniques. Finally, an original and sensitive cytotoxicity assay which consists on the measurement of total RNA cells synthesis was used to prove the non-toxicity of both obtained nanohybrids.

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Publication details

The article was received on 15 Aug 2017, accepted on 13 Oct 2017 and first published on 13 Oct 2017


Article type: Paper
DOI: 10.1039/C7DT03029K
Citation: Dalton Trans., 2017, Accepted Manuscript
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    Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier

    F. Sallem, J. Boudon, O. HEINTZ, I. Séverin, A. Megriche and N. Millot, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT03029K

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