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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

Abstract

Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1-4 are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1 elicits its cytotoxic effect by elevating intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

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Publication details

The article was received on 30 Jul 2017, accepted on 03 Sep 2017 and first published on 04 Sep 2017


Article type: Communication
DOI: 10.1039/C7DT02789C
Citation: Dalton Trans., 2017, Accepted Manuscript
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    A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

    C. Lu, K. Laws, A. Eskandari and K. Suntharalingam, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02789C

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