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A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

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Abstract

Tetranuclear copper(II) complexes containing multiple diclofenac and Schiff base moieties, 1–4, are shown to kill bulk cancer cells and cancer stem cells (CSCs) with low micromolar potency. The most effective complex, 1, elicits its cytotoxic effect by elevating the intracellular reactive oxygen species (ROS) levels and inhibiting cyclooxygenase-2 (COX-2) expression.

Graphical abstract: A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(ii) cluster

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Publication details

The article was received on 30 Jul 2017, accepted on 03 Sep 2017 and first published on 04 Sep 2017


Article type: Communication
DOI: 10.1039/C7DT02789C
Citation: Dalton Trans., 2017, Advance Article
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    A reactive oxygen species-generating, cyclooxygenase-2 inhibiting, cancer stem cell-potent tetranuclear copper(II) cluster

    C. Lu, K. Laws, A. Eskandari and K. Suntharalingam, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT02789C

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