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Near-infrared light-mediated LA-UCNPs@SiO2-C/HA@mSiO2-DOX@NB nanocomposite for chemotherapy /PDT/ PTT and imaging

Abstract

Currently, the incorporating multiple therapeutic functions into one nanoplantform has attracted more and more attention for the development of efficient anticancer agents. Here, a novel core-shell-shell nanoparticle, which was synthesized to integrate imaging and photodynamic therapy (PDT) with photothermal therapy (PTT) and chemotherapy for enhanced antitumor efficiency, consists of upconversion (UC) core (NaYF4:Yb,Tm@NaYF4), Hypocrellin A (HA)/carbon dots (C-Dots) embodied silica sandwich shell, and mesoporous silica outer-shell. A photolabile o-nitrobenzyl derivative linker (NB linker) was prepared as the sensitive “gate” to encapsulate anticancer drug (doxorubicin hydrochloride, DOX) in the mesopore. Upon 980 nm light irradiation, the UV-emission can induce the bond breaking of NB linker as well as drug release. The visible emission can stimulate HA to generate singlet oxygen species (ROS), moreover the incorporated C-Dots also can absorb these light to evolve heat. To further make sure the specific targeting, lactobionic acid (LA) was grafted outside due to the excess expression of LA receptor on tumor cells. The synergistic effecting of NIR-triggered chemotherapy with PTT and PDT would be expected to reveal the enhanced cytotoxicity to cancer cells. And the novel UC and C/HA fluorescence also make the nanocomposites as the potential candidate for the imaging-guided multi-therapy.

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Supplementary files

Publication details

The article was received on 12 Jul 2017, accepted on 14 Sep 2017 and first published on 15 Sep 2017


Article type: Paper
DOI: 10.1039/C7DT02529G
Citation: Dalton Trans., 2017, Accepted Manuscript
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    Near-infrared light-mediated LA-UCNPs@SiO2-C/HA@mSiO2-DOX@NB nanocomposite for chemotherapy /PDT/ PTT and imaging

    Y. H. Chen, F. Zhang, Q. Wang, R. Tong, H. Lin and F. Qu, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02529G

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