Jump to main content
Jump to site search


A chemosensor for micro- to nano-molar detection of Ag+ and Hg2+ ions in pure aqueous media and its applications in cell imaging

Author affiliations

Abstract

The pyridine substituted thiourea derivative PTB-1 was synthesized and characterized by spectroscopic techniques as well as by single crystal X-ray crystallography. The metal ion sensing ability of PTB-1 was explored by various experimental (naked-eye, UV-Vis, fluorescence, mass spectrometry and 1H NMR spectroscopy) and theoretical (B3LYP/6-31G**/LANL2DZ) methods. PTB-1 exhibited a highly selective naked-eye detectable color change from colorless to dark brown and UV-Vis spectral changes for the detection of Ag+ with a detection limit of 3.67 μM in aqueous medium. The detection of Ag+ ions was achieved by test paper strip and supported silica methods. In contrast, PTB-1 exhibited a 23-fold enhanced emission at 420 nm in the presence of Hg2+ ions with a nano-molar detection limit of 0.69 nM. Finally, the sensor PTB-1 was applied successfully for the intracellular detection of Hg2+ ions in a HepG2 liver cell line, which was monitored by the use of confocal imaging techniques.

Graphical abstract: A chemosensor for micro- to nano-molar detection of Ag+ and Hg2+ ions in pure aqueous media and its applications in cell imaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jul 2017, accepted on 19 Sep 2017 and first published on 19 Sep 2017


Article type: Paper
DOI: 10.1039/C7DT02524F
Citation: Dalton Trans., 2017, Advance Article
  •   Request permissions

    A chemosensor for micro- to nano-molar detection of Ag+ and Hg2+ ions in pure aqueous media and its applications in cell imaging

    J. P. Nandre, S. R. Patil, S. K. Sahoo, C. P. Pradeep, A. Churakov, F. Yu, L. Chen, C. Redshaw, A. A. Patil and U. D. Patil, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT02524F

Search articles by author

Spotlight

Advertisements