Jump to main content
Jump to site search


Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

Abstract

Two anticancer gold(III) compounds, Au2phen and Auoxo4, were encapsulated within the ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(I) ions bind Ft within the cage, close to side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(I)-loaded Ft, obtained upon encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Jun 2017, accepted on 05 Oct 2017 and first published on 05 Oct 2017


Article type: Paper
DOI: 10.1039/C7DT02370G
Citation: Dalton Trans., 2017, Accepted Manuscript
  •   Request permissions

    Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

    D. M. Monti, G. Ferraro, G. Petruk, L. Maiore, F. Pane, A. Amoresano, M. A. Cinellu and A. Merlino, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02370G

Search articles by author

Spotlight

Advertisements