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Issue 44, 2017
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Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

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Abstract

Two anticancer gold(III) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(I) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(I)-loaded Ft, obtained upon the encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.

Graphical abstract: Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

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Publication details

The article was received on 30 Jun 2017, accepted on 05 Oct 2017 and first published on 05 Oct 2017


Article type: Paper
DOI: 10.1039/C7DT02370G
Citation: Dalton Trans., 2017,46, 15354-15362
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    Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells

    D. M. Monti, G. Ferraro, G. Petruk, L. Maiore, F. Pane, A. Amoresano, M. A. Cinellu and A. Merlino, Dalton Trans., 2017, 46, 15354
    DOI: 10.1039/C7DT02370G

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