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A Highly Stable L-Alanine-Based Mono(aquated) Mn(II) Complex as T1-weighted MRI Contrast Agent

Abstract

The synthesized lithium (S)-6,6'-(1-carboxyethylazanediyl)bis(methylene)dipicolinate (Li3cbda) was a new chiral, alanine-based ligand bearing two picolinic acid functionalities. The trianionic form of the ligand [(cbda)3-] constituted a seven-coordinate, water-soluble, pentagonal bipyramidal Mn(II) complex (1). The structural analysis revealed the presence of a water coordinating site in the complex. The complex was thermodynamically very stable and the stability was not being challenged by the presence of physiological anions (HCO3-, PO43-, F-). The pH of the medium exerted a little effect on the stability of the complex. The r1 relaxivity 3.02 mM-1s-1 was exhibited by the complex at 1.41 T, pH ~ 7.4, 25 °C. Phantom images measured by clinical MRI imager BRIVO MR355 established concentration-dependent signal enhancement by the complex. The cytotoxixity test consolidated complex 1 as a biocompatible potential T1-weighted MRI contrast agent.

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Publication details

The article was received on 26 Jun 2017, accepted on 07 Jul 2017 and first published on 07 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02282D
Citation: Dalton Trans., 2017, Accepted Manuscript
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    A Highly Stable L-Alanine-Based Mono(aquated) Mn(II) Complex as T1-weighted MRI Contrast Agent

    C. Mukherjee, M. Khannam, T. Weyhermueller and U. Goswami, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02282D

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