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Issue 31, 2017
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A highly stable L-alanine-based mono(aquated) Mn(II) complex as a T1-weighted MRI contrast agent

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Abstract

The synthesized lithium (S)-6,6′-(1-carboxyethylazanediyl)bis(methylene)dipicolinate (Li3cbda) is a new chiral, alanine-based ligand bearing two picolinate functionalities. The trianionic form of the ligand [(cbda)3−] constitutes a seven-coordinate, water-soluble, pentagonal bipyramidal Mn(II) complex (1). The structural analysis reveals the presence of a water coordinating site in the complex. The complex is thermodynamically very stable, and the stability is not affected by the presence of physiological anions (HCO3, PO43−, and F). The pH of the medium exerts a small effect on the stability of the complex. The r1 relaxivity of 3.02 mM−1 s−1 is exhibited by the complex at 1.41 T, pH ∼7.4, and 25 °C. Phantom images obtained via a clinical MRI BRIVO MR355 system established concentration-dependent signal enhancement by the complex. The cytotoxicity test confirmed complex 1 as a biocompatible potential T1-weighted MRI contrast agent.

Graphical abstract: A highly stable l-alanine-based mono(aquated) Mn(ii) complex as a T1-weighted MRI contrast agent

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Publication details

The article was received on 26 Jun 2017, accepted on 07 Jul 2017 and first published on 07 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02282D
Citation: Dalton Trans., 2017,46, 10426-10432
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    A highly stable L-alanine-based mono(aquated) Mn(II) complex as a T1-weighted MRI contrast agent

    M. Khannam, T. Weyhermüller, U. Goswami and C. Mukherjee, Dalton Trans., 2017, 46, 10426
    DOI: 10.1039/C7DT02282D

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