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Issue 35, 2017
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Phototoxicity of strained Ru(II) complexes: is it the metal complex or the dissociating ligand?

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Abstract

A photochemically dissociating ligand in Ru(bpy)2(dmphen)Cl2 [bpy = 2,2′-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)2(H2O)22+ and prototypical cisplatin. Our findings illustrate the potential potency of diimine ligands in photoactivatable Ru(II) complexes.

Graphical abstract: Phototoxicity of strained Ru(ii) complexes: is it the metal complex or the dissociating ligand?

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Publication details

The article was received on 21 Jun 2017, accepted on 12 Jul 2017 and first published on 13 Jul 2017


Article type: Communication
DOI: 10.1039/C7DT02255G
Citation: Dalton Trans., 2017,46, 11529-11532
  • Open access: Creative Commons BY-NC license
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    Phototoxicity of strained Ru(II) complexes: is it the metal complex or the dissociating ligand?

    D. F. Azar, H. Audi, S. Farhat, M. El-Sibai, R. J. Abi-Habib and R. S. Khnayzer, Dalton Trans., 2017, 46, 11529
    DOI: 10.1039/C7DT02255G

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