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Issue 34, 2017
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pH-Driven preparation of two related platinum(II) complexes exhibiting distinct cytotoxic properties

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Abstract

Reaction of cis-[PtCl2(DMSO)2] with the ligand 4-methyl-2-N-(2-pyridylmethylene)aminophenol (Hpyrimol, LH) in methanol at room temperature produces the complexes [PtCl2LH] or [PtClL], under acidic or basic conditions, respectively. The two platinum compounds exhibit distinct DNA-interacting properties, [PtCl2LH] showing a higher affinity for the biomolecules. Furthermore, [PtClL] is clearly more cytotoxic than [PtCl2LH] in three different cancer cell lines. Solution studies reveal the occurrence of intricate solvation processes generating different aquated/hydroxido species, whose nature depends on the starting metal complex and the pH of the medium.

Graphical abstract: pH-Driven preparation of two related platinum(ii) complexes exhibiting distinct cytotoxic properties

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Publication details

The article was received on 11 Jun 2017, accepted on 24 Jul 2017 and first published on 25 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02127E
Citation: Dalton Trans., 2017,46, 11214-11222
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    pH-Driven preparation of two related platinum(II) complexes exhibiting distinct cytotoxic properties

    J. Molas Saborit, A. Caubet, R. F. Brissos, L. Korrodi-Gregório, R. Pérez-Tomás, M. Martínez and P. Gamez, Dalton Trans., 2017, 46, 11214
    DOI: 10.1039/C7DT02127E

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