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[AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange

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Abstract

Radiofluorination of a 2.63 μM solution (pH 4, NaOAc buffer) of [AlCl3(BnMe2-tacn)] via treatment with 2.99 mol. equiv. of [19F]KF doped with cyclotron-produced [18F]F target water, with heating to 80–100 °C for 1 h, gives up to 24% 18F incorporation. SPE purification of the [Al19F218F(BnMe2-tacn)] radio-product gives >99% RCP, with excellent stability (>99% RCP after 3 h).

Graphical abstract: [AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange

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Publication details

The article was received on 11 Jun 2017, accepted on 09 Aug 2017 and first published on 09 Aug 2017


Article type: Communication
DOI: 10.1039/C7DT02122D
Citation: Dalton Trans., 2017, Advance Article
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    [AlCl3(BnMe2-tacn)] – a new metal chelate scaffold for radiofluorination by Cl/F exchange

    W. Levason, S. K. Luthra, G. McRobbie, F. M. Monzittu and G. Reid, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT02122D

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