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Synthesis and evaluation of biological properties of ferrocenyl-podophyllotoxin conjugates

Abstract

Three types, esters, amides and 1,2,3-triazoles of ferrocenyl-podophyllotoxin conjugates were synthesised, and their anticancer activity was evaluated. We observed that the most potent ferrocenyl derivatives were esters. Esters 15, 16 and 17 acted in a way similar to podophyllotoxin, i.e. reduced the number of G1 phase cells and induced G2/M blockage, while esters 14, 18, and amide 19 blocked cells in S phase in a similar manner to etoposide.

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Publication details

The article was received on 09 Jun 2017, accepted on 13 Jul 2017 and first published on 14 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02107K
Citation: Dalton Trans., 2017, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Synthesis and evaluation of biological properties of ferrocenyl-podophyllotoxin conjugates

    A. Wieczorek, A. Błauż, A. M. Makal, B. Rychlik and D. Plazuk, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT02107K

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