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Issue 33, 2017
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Synthesis and evaluation of biological properties of ferrocenyl–podophyllotoxin conjugates

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Abstract

Three types, esters, amides and 1,2,3-triazoles, of ferrocenyl–podophyllotoxin conjugates were synthesised, and their anticancer activity was evaluated. We observed that the most potent ferrocenyl derivatives were esters. Esters 15, 16 and 17 acted in a similar way to podophyllotoxin, i.e. reduced the number of G1 phase cells and induced G2/M blockage, while esters 14 and 18 and amide 19 blocked cells in S phase in a similar manner to etoposide.

Graphical abstract: Synthesis and evaluation of biological properties of ferrocenyl–podophyllotoxin conjugates

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Publication details

The article was received on 09 Jun 2017, accepted on 13 Jul 2017 and first published on 14 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02107K
Citation: Dalton Trans., 2017,46, 10847-10858
  • Open access: Creative Commons BY-NC license
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    Synthesis and evaluation of biological properties of ferrocenyl–podophyllotoxin conjugates

    A. Wieczorek, A. Błauż, A. Makal, B. Rychlik and D. Plażuk, Dalton Trans., 2017, 46, 10847
    DOI: 10.1039/C7DT02107K

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