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Issue 36, 2017
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A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

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Abstract

Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(η6-p-cymene)Cl2] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule. Evaluation of the compounds on human ovarian cancer cells reveals synergistic enhancements in their antiproliferative activity relative to their bioactive organic and organometallic precursors.

Graphical abstract: A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

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Publication details

The article was received on 06 Jun 2017, accepted on 09 Jun 2017 and first published on 19 Jun 2017


Article type: Communication
DOI: 10.1039/C7DT02062G
Citation: Dalton Trans., 2017,46, 12001-12004
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    A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

    L. Biancalana, L. K. Batchelor, A. De Palo, S. Zacchini, G. Pampaloni, P. J. Dyson and F. Marchetti, Dalton Trans., 2017, 46, 12001
    DOI: 10.1039/C7DT02062G

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