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Issue 30, 2017
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Ru(II)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines

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Abstract

A series of novel ruthenium(II) 2,2′-bipyridyl (bpy) and 1,10-phenanthroline (phen) derivatives containing PTA (1,3,5-triaza-7-phosphaadamantane) or mPTA (N-methyl-1,3,5-triaza-7-phosphaadamantane cation) have been synthesized and fully characterized. Three types of complexes have been obtained, neutral [Ru(N–N)(PTA)2Cl2] (1, N–N = bpy and 4, N–N = phen), monocationic [Ru(N–N)(PTA)3Cl][Cl] (2, N–N = bpy and 5, N–N = phen) and dicationic [Ru(N–N)(mPTA)Cl2][BF4]2 (3, N–N = bpy and 6, N–N = phen). The solid-state structures of four complexes have been determined by single-crystal X-ray diffraction. The cytotoxicity of the complexes has been evaluated in vitro against U266 and RPMI human multiple myeloma cells.

Graphical abstract: Ru(ii)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines

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Publication details

The article was received on 05 Jun 2017, accepted on 04 Jul 2017 and first published on 07 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02051A
Citation: Dalton Trans., 2017,46, 10073-10081
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    Ru(II)-(PTA) and -mPTA complexes with N2-donor ligands bipyridyl and phenanthroline and their antiproliferative activities on human multiple myeloma cell lines

    A. Wołoszyn, C. Pettinari, R. Pettinari, G. V. Badillo Patzmay, A. Kwiecień, G. Lupidi, M. Nabissi, G. Santoni and P. Smoleński, Dalton Trans., 2017, 46, 10073
    DOI: 10.1039/C7DT02051A

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