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Issue 34, 2017
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Synthesis and characterization of FeIII(μ-OH)ZnII complexes: effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA

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Abstract

The synthesis and characterization of three ligands and their respective heterobinuclear FeIIIZnII complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H2L2) was synthesized and its complex (FeIIIZnIIL2) was used as a basis for comparison with similar complexes previously published in the literature. Subsequent modifications were conducted in the aldehyde group, where 1,2-ethanediamine and 1,4-diaminobutane were used as side chain derivatives. The compounds FeIIIZnIIL2 (1), FeIIIZnIIL2-et (2) and FeIIIZnIIL2-but (3) were characterized by spectroscopic methods (infrared and UV-Vis) and ESI-MS spectrometry. Theoretical calculations were performed to provide insights into the complex structures with FeIIIZnII structures. The hydrolytic activity was analyzed both with the model substrate 2,4-BDNPP and with DNA catalyzed by complexes 1, 2 and 3.

Graphical abstract: Synthesis and characterization of FeIII(μ-OH)ZnII complexes: effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA

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Publication details

The article was received on 05 Jun 2017, accepted on 29 Jul 2017 and first published on 31 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT02035J
Citation: Dalton Trans., 2017,46, 11380-11394
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    Synthesis and characterization of FeIII(μ-OH)ZnII complexes: effects of a second coordination sphere and increase in the chelate ring size on the hydrolysis of a phosphate diester and DNA

    G. A. D. S. Silva, A. L. Amorim, B. D. Souza, P. Gabriel, H. Terenzi, E. Nordlander, A. Neves and R. A. Peralta, Dalton Trans., 2017, 46, 11380
    DOI: 10.1039/C7DT02035J

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