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Issue 25, 2017
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Enhancement of the antiproliferative activity of [RuCp(PPh3)2(dmoPTA-1κP)]+via its coordination to one {CoCl2} unit: synthesis, crystal structure and properties of [RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2N,N′-CoCl2](OTf)·0.25H2O

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Abstract

Synthesis, characterization and the antiproliferative activity of a new bimetallic complex [RuCp(PPh3)2-μ-dmoPTA-1κP:2k2N,N′-CoCl2]OTf·0.25H2O are described. The stability of the complex was studied under air and N2 atmospheres and in CDCl3, DMSO, water and the cell culture medium, at room temperature and 40 °C. The complex showed an enhanced antiproliferative activity (up to six-fold) when compared with its parent complex [RuCp(PPh3)2(HdmoPTA)]2+ against human lung, cervix, breast, and colon solid tumor cell lines.

Graphical abstract: Enhancement of the antiproliferative activity of [RuCp(PPh3)2(dmoPTA-1κP)]+via its coordination to one {CoCl2} unit: synthesis, crystal structure and properties of [RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2N,N′-CoCl2](OTf)·0.25H2O

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Publication details

The article was received on 12 May 2017, accepted on 31 May 2017 and first published on 31 May 2017


Article type: Communication
DOI: 10.1039/C7DT01741C
Citation: Dalton Trans., 2017,46, 8009-8012
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    Enhancement of the antiproliferative activity of [RuCp(PPh3)2(dmoPTA-1κP)]+via its coordination to one {CoCl2} unit: synthesis, crystal structure and properties of [RuCp(PPh3)2-μ-dmoPTA-1κP:2κ2N,N′-CoCl2](OTf)·0.25H2O

    Z. Mendoza, P. Lorenzo-Luis, F. Scalambra, J. M. Padrón and A. Romerosa, Dalton Trans., 2017, 46, 8009
    DOI: 10.1039/C7DT01741C

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