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Issue 39, 2017
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Copper induced spin state change of heme–Aβ associated with Alzheimer's disease

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Abstract

Heme binds Aβ to give a mixture of a mono-histidine bound high spin peroxidase type active site and a bis-histidine bound low spin cytochrome b type active site present in an equilibrium at physiological pH. Of these, the high spin mono-histidine bound complexes produce significant amounts of partially reduced oxygen species (PROS), catalyze the degradation of neurotransmitters and oxidize cytochrome c, with potentially detrimental effects. The presence of excess Aβ could lower these effects by creating a low spin bis-histidine cytochrome b type active site which exerts less oxidative stress by producing a much smaller amount of PROS. The presence of Cu(II) reverses this effect and can convert the benign low spin heme–Aβ complex to the detrimental high spin form, even in the presence of excess Aβ. Data suggest that the histidine needed to form the bis-histidine site in the low spin heme–Aβ complex is likely to be involved in the high affinity Cu binding site in the heme–Cu–Aβ complex.

Graphical abstract: Copper induced spin state change of heme–Aβ associated with Alzheimer's disease

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Publication details

The article was received on 10 May 2017, accepted on 19 Jun 2017 and first published on 22 Jun 2017


Article type: Communication
DOI: 10.1039/C7DT01700F
Citation: Dalton Trans., 2017,46, 13171-13175
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    Copper induced spin state change of heme–Aβ associated with Alzheimer's disease

    S. Mukherjee, C. Ghosh, M. Seal and S. G. Dey, Dalton Trans., 2017, 46, 13171
    DOI: 10.1039/C7DT01700F

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