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Issue 28, 2017
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Oxaliplatin reacts with DMSO only in the presence of water

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Abstract

Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(II) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR and RP-HPLC techniques.

Graphical abstract: Oxaliplatin reacts with DMSO only in the presence of water

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Publication details

The article was received on 04 May 2017, accepted on 05 Jun 2017 and first published on 27 Jun 2017


Article type: Communication
DOI: 10.1039/C7DT01628J
Citation: Dalton Trans., 2017,46, 8929-8932
  • Open access: Creative Commons BY license
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    Oxaliplatin reacts with DMSO only in the presence of water

    H. P. Varbanov, D. Ortiz, D. Höfer, L. Menin, M. Galanski, B. K. Keppler and P. J. Dyson, Dalton Trans., 2017, 46, 8929
    DOI: 10.1039/C7DT01628J

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