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Issue 23, 2017
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A luminescent ratiometric pH sensor based on a nanoscale and biocompatible Eu/Tb-mixed MOF

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Abstract

The precise and real-time monitoring of localized pH changes is of great importance in many engineering and environmental fields, especially for monitoring small pH changes in biological environments and living cells. Metal–organic frameworks (MOFs) with their nanoscale processability show very promising applications in bioimaging and biomonitoring, but the fabrication of nanoscale MOFs is still a challenge. In this study, we synthesized a nanoscale mixed-lanthanide metal–organic framework by a microemulsion method. The morphology and size of the NMOF can be simply adjusted by the addition of different amounts of the CTAB surfactant. This NMOF exhibits significant pH-dependent luminescence emission, which can act as a self-referenced pH sensor based on two emissions of Tb3+ at 545 nm and Eu3+ at 618 nm in the pH range from 3.00 to 7.00. The MTT assay and optical microscopy assay demonstrate the low cytotoxicity and good biocompatibility of the nanosensor.

Graphical abstract: A luminescent ratiometric pH sensor based on a nanoscale and biocompatible Eu/Tb-mixed MOF

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Publication details

The article was received on 02 May 2017, accepted on 15 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7DT01604B
Citation: Dalton Trans., 2017,46, 7549-7555
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    A luminescent ratiometric pH sensor based on a nanoscale and biocompatible Eu/Tb-mixed MOF

    T. Xia, F. Zhu, K. Jiang, Y. Cui, Y. Yang and G. Qian, Dalton Trans., 2017, 46, 7549
    DOI: 10.1039/C7DT01604B

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