Issue 29, 2017
From the journal:

Dalton Transactions

Primary photochemical processes for Pt(iv) diazido complexes prospective in photodynamic therapy of tumors†

Anton A. Shushakov,ab   Ivan P. Pozdnyakov,ab   Vjacheslav P. Grivin,a   Victor F. Plyusnin,ab   Danila B. Vasilchenko, ORCID logo cb   Andrei V. Zadesenets,cb   Alexei A. Melnikov,d   Sergey V. Chekalind  and  Evgeni M. Glebov ORCID logo *ab  

* Corresponding authors

a Voevodsky Institute of Chemical Kinetics and Combustion, 3 Institutskaya Str., Novosibirsk, Russian Federation
E-mail: glebov@kinetics.nsc.ru
Fax: +7383 3307350
Tel: +7 383 3309150

b Novosibirsk State University, 2 Pirogova Str., Novosibirsk, Russian Federation

c Nikolaev Institute of Inorganic Chemistry, 3 Lavrentiev Ave., 119333, Novosibirsk, Russian Federation
E-mail: vasilchenko@niic.nsc.ru

d Institute of Spectroscopy, Russian Academy of Sciences, 5 Fizicheskaya Str., Troitsk, Moscow, Russian Federation
E-mail: melnikov@isan.troitsk.ru

Abstract

Diazide diamino complexes of Pt(IV) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N3)2(OH)2(NH3)2] and trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(IV) and Pt(III) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed.

Graphical abstract: Primary photochemical processes for Pt(iv) diazido complexes prospective in photodynamic therapy of tumors

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Article information

DOI
https://doi.org/10.1039/C7DT01529A
Article type
Paper
Submitted
27 Apr 2017
Accepted
03 Jul 2017
First published
03 Jul 2017
This article is Open Access
Creative Commons BY license

Dalton Trans., 2017,46, 9440-9450

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Primary photochemical processes for Pt(IV) diazido complexes prospective in photodynamic therapy of tumors

A. A. Shushakov, I. P. Pozdnyakov, V. P. Grivin, V. F. Plyusnin, D. B. Vasilchenko, A. V. Zadesenets, A. A. Melnikov, S. V. Chekalin and E. M. Glebov, Dalton Trans., 2017, 46, 9440 DOI: 10.1039/C7DT01529A

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