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Issue 29, 2017
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Primary photochemical processes for Pt(IV) diazido complexes prospective in photodynamic therapy of tumors

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Abstract

Diazide diamino complexes of Pt(IV) are considered as prospective prodrugs in oxygen-free photodynamic therapy (PDT). Primary photophysical and photochemical processes for cis,trans,cis-[Pt(N3)2(OH)2(NH3)2] and trans,trans,trans-[Pt(N3)2(OH)2(NH3)2] complexes were studied by means of stationary photolysis, nanosecond laser flash photolysis and ultrafast kinetic spectroscopy. The process of photolysis is multistage. The first stage is the photosubstitution of an azide ligand to a water molecule. This process was shown to be a chain reaction involving redox stages. Pt(IV) and Pt(III) intermediates responsible for the chain propagation were recorded using ultrafast kinetic spectroscopy and nanosecond laser flash photolysis. The mechanism of photosubstitution is proposed.

Graphical abstract: Primary photochemical processes for Pt(iv) diazido complexes prospective in photodynamic therapy of tumors

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Publication details

The article was received on 27 Apr 2017, accepted on 03 Jul 2017 and first published on 03 Jul 2017


Article type: Paper
DOI: 10.1039/C7DT01529A
Citation: Dalton Trans., 2017,46, 9440-9450
  • Open access: Creative Commons BY license
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    Primary photochemical processes for Pt(IV) diazido complexes prospective in photodynamic therapy of tumors

    A. A. Shushakov, I. P. Pozdnyakov, V. P. Grivin, V. F. Plyusnin, D. B. Vasilchenko, A. V. Zadesenets, A. A. Melnikov, S. V. Chekalin and E. M. Glebov, Dalton Trans., 2017, 46, 9440
    DOI: 10.1039/C7DT01529A

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