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A glycosylation strategy to develop low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium

Abstract

A glycosylation strategy based on click chemistry was employed to develop naphthalimide-based Fe3+ fluorescent probe with low cytotoxicity and good water-solubility. The selectivity and sensitivity to Fe3+ of three synthesized naphthalimide-based fluorescent probes follows a Nap-PZ<Nap-OH<Nap-Glc trend, because the exposed toxic group of Nap-PZ was shielded by good biocompatible group. The detection limit toward Fe3+ ion follows a Nap-PZ(7.4010-6M)>Nap-OH(2.7310-7M)>Nap-Glc(4.2710-8M) trend. Moreover, Nap-Glc could be used to detect Fe3+ in living cells. The fluorescent “off-on” response of Nap-Glc towards Fe3+ could be recognized by naked-eye, and the “off-on” fluorescent mechanism was demonstrated by theoretical calculations. Therefore, Nap-Glc was a novel glucosyl naphthalimide fluorescent probe for environmental or biological detection of Fe3+ with low cytotoxicity and good water-solubility.

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Publication details

The article was received on 27 Mar 2017, accepted on 15 May 2017 and first published on 16 May 2017


Article type: Paper
DOI: 10.1039/C7DT01099K
Citation: Dalton Trans., 2017, Accepted Manuscript
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    A glycosylation strategy to develop low toxic naphthalimide fluorescent probe for the detection of Fe3+ in aqueous medium

    F. Liu, P. Tang, R. Ding, L. Liao, L. Wang, M. Wang and J. Wang, Dalton Trans., 2017, Accepted Manuscript , DOI: 10.1039/C7DT01099K

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