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A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

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Abstract

One of the most attractive areas in inorganic chemistry is the synthesis of polyoxometalates (POMs) exhibiting new properties and applications. Since the impact of POMs in biochemistry and related fields of research has increased in the last few years, there has been a special interest in this topic. Significant progress in biological applications has been made where the interaction of POMs with amino acids, peptides and proteins is relevant. Versatile POMs play a series of different roles in the interaction with these biomolecules as described in this review. Various types of interactions are established, depending on the POM shape and charge, the amino acid side chain, peptide sequence or protein structure. Experimental conditions such as temperature, acidity, solvent, etc. are also important factors that influence the binding/reactivity of POM with biomolecules, as described herein. This understanding allows the adequate design of the POM-biomolecule couple for tailoring and controlling mechanisms of action such as catalysis, inhibition, and aggregation, or the crystallising agent.

Graphical abstract: A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

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Publication details

The article was received on 11 Mar 2017, accepted on 02 May 2017 and first published on 02 May 2017


Article type: Perspective
DOI: 10.1039/C7DT00894E
Citation: Dalton Trans., 2017, Advance Article
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    A survey of the different roles of polyoxometalates in their interaction with amino acids, peptides and proteins

    M. Arefian, M. Mirzaei, H. Eshtiagh-Hosseini and A. Frontera, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT00894E

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