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Issue 13, 2017
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A metal ion regulated artificial metalloenzyme

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Abstract

Regulation of enzyme activity is essential in living cells. The rapidly increasing number of designer enzymes with new-to-nature activities makes it necessary to develop novel strategies for controlling their catalytic activity. Here we present the development of a metal ion regulated artificial metalloenzyme created by combining two anchoring strategies, covalent and supramolecular, for introducing a regulatory and a catalytic site, respectively. This artificial metalloenzyme is activated in the presence of Fe2+ ions, but only marginally in the presence of Zn2+.

Graphical abstract: A metal ion regulated artificial metalloenzyme

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Publication details

The article was received on 13 Feb 2017, accepted on 27 Feb 2017, published on 27 Feb 2017 and first published online on 27 Feb 2017


Article type: Paper
DOI: 10.1039/C7DT00533D
Citation: Dalton Trans., 2017,46, 4325-4330
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    A metal ion regulated artificial metalloenzyme

    M. Bersellini and G. Roelfes, Dalton Trans., 2017, 46, 4325
    DOI: 10.1039/C7DT00533D

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