Jump to main content
Jump to site search

Issue 27, 2017
Previous Article Next Article

The thrombogenic activity of POSS silanols

Author affiliations


In vitro studies into the interaction of polyhedral oligomeric silsesquioxane (POSS) trisilanols with porcine and human red blood cells (erythrocytes), and mouse fibroblasts is reported. The observations are in agreement with previously reported erythrocyte activity of silanol containing minerals. However the multifunctionality imparted by the POSS silanols provides for their expansion of utility in traumatic hemorrhage and wound care. Further, in vitro tissue studies of i-octyltrisilanol POSS cages are in agreement with reported findings of related POSS serving as tissue scaffolds by providing cellular binding sites and porosity for cellular taxis. The resulting effect is increased rates of tissue healing.

Graphical abstract: The thrombogenic activity of POSS silanols

Back to tab navigation

Publication details

The article was received on 08 Feb 2017, accepted on 02 Mar 2017 and first published on 09 Mar 2017

Article type: Paper
DOI: 10.1039/C7DT00487G
Citation: Dalton Trans., 2017,46, 8788-8796
  •   Request permissions

    The thrombogenic activity of POSS silanols

    J. D. Lichtenhan, D. A. Hildebrandt and L. J. Lancaster, Dalton Trans., 2017, 46, 8788
    DOI: 10.1039/C7DT00487G

Search articles by author