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The thrombogenic activity of POSS silanols

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Abstract

In vitro studies into the interaction of polyhedral oligomeric silsesquioxane (POSS) trisilanols with porcine and human red blood cells (erythrocytes), and mouse fibroblasts is reported. The observations are in agreement with previously reported erythrocyte activity of silanol containing minerals. However the multifunctionality imparted by the POSS silanols provides for their expansion of utility in traumatic hemorrhage and wound care. Further, in vitro tissue studies of i-octyltrisilanol POSS cages are in agreement with reported findings of related POSS serving as tissue scaffolds by providing cellular binding sites and porosity for cellular taxis. The resulting effect is increased rates of tissue healing.

Graphical abstract: The thrombogenic activity of POSS silanols

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Publication details

The article was received on 08 Feb 2017, accepted on 02 Mar 2017, published on 09 Mar 2017 and first published online on 09 Mar 2017


Article type: Paper
DOI: 10.1039/C7DT00487G
Citation: Dalton Trans., 2017, Advance Article
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    The thrombogenic activity of POSS silanols

    J. D. Lichtenhan, D. A. Hildebrandt and L. J. Lancaster, Dalton Trans., 2017, Advance Article , DOI: 10.1039/C7DT00487G

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