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Issue 12, 2017
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A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

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Abstract

Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.

Graphical abstract: A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

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Publication details

The article was received on 17 Jan 2017, accepted on 28 Feb 2017, published on 28 Feb 2017 and first published online on 28 Feb 2017


Article type: Paper
DOI: 10.1039/C7DT00195A
Citation: Dalton Trans., 2017,46, 3915-3920
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    A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

    S. E. Russell, J. M. González Carballo, C. Orellana-Tavra, D. Fairen-Jimenez and R. E. Morris, Dalton Trans., 2017, 46, 3915
    DOI: 10.1039/C7DT00195A

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