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Issue 16, 2017
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Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae

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Abstract

HutZ is a heme-degrading enzyme. We found that the heme-degradation reaction by HutZ is inhibited by the iron chelators. Kinetic analysis of each heme-degradation step suggests that water molecules hydrogen bonded to Thr27 are involved in proton transfer to Fe(III)–OO, and that this step is inhibited by iron chelators.

Graphical abstract: Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae

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Publication details

The article was received on 12 Jan 2017, accepted on 17 Mar 2017 and first published on 17 Mar 2017


Article type: Communication
DOI: 10.1039/C7DT00121E
Citation: Dalton Trans., 2017,46, 5147-5150
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    Iron chelators inhibit the heme-degradation reaction by HutZ from Vibrio cholerae

    N. Dojun, Y. Sekine, K. Ishimori and T. Uchida, Dalton Trans., 2017, 46, 5147
    DOI: 10.1039/C7DT00121E

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