Jump to main content
Jump to site search

Issue 27, 2017
Previous Article Next Article

Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

Author affiliations

Abstract

Gold nanoparticles (AuNPs) and polycationic macromolecules are used as gene carriers. Their behaviour is dependent on several factors, such as the size and type of the framework, charge, etc. We have combined both types of systems and prepared AuNPs covered with cationic carbosilane dendrons with the aim to evaluate their biocompatibility. Water soluble dendronized cationic AuNPs were prepared following a straightforward procedure from dendrons, a gold precursor and a reducing agent in water and were characterized by 1H NMR, transmission electron microscopy (TEM), dynamic light scattering (DLS), thermogravimetric analysis (TGA), ultraviolet spectroscopy (UV), and zeta potential (ZP). The biological properties of dendrons and AuNPs were determined by hemolysis, platelet aggregation and lymphocyte proliferation. These assays reflect modification of dendron properties when covering nanoparticles. For dendrons, hemolysis and platelet aggregation are generation dependent whilst, for AuNPs these properties are related to the bigger size of NPs. On the other hand, none of the systems induced lymphocyte proliferation. Selected cationic dendrons and AuNPs were chosen for gene delivery experiments employing a small interference RNA (siRNA Nef) against human immunodeficiency virus (HIV).

Graphical abstract: Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Sep 2016, accepted on 15 Dec 2016 and first published on 16 Dec 2016


Article type: Paper
DOI: 10.1039/C6DT03791G
Citation: Dalton Trans., 2017,46, 8736-8745
  •   Request permissions

    Gold nanoparticles stabilized by cationic carbosilane dendrons: synthesis and biological properties

    C. E. Peña-González, E. Pedziwiatr-Werbicka, D. Shcharbin, C. Guerrero-Beltrán, V. Abashkin, S. Loznikova, J. L. Jiménez, M. Á. Muñoz-Fernández, M. Bryszewska, R. Gómez, J. Sánchez-Nieves and F. J. de la Mata, Dalton Trans., 2017, 46, 8736
    DOI: 10.1039/C6DT03791G

Search articles by author

Spotlight

Advertisements