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One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system

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Abstract

A rare example of a one-pot, palladium-catalyzed Suzuki–Heck sequence has been developed with applicability to APIs and organoelectronic materials. High throughput screening was used to expedite development and survey strategies. Interchangeability of the coupling partners and the avoidance of intermediate isolation gives operational flexibility, which can be used to improve process efficiency and suppress by-product formation.

Graphical abstract: One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system

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Publication details

The article was received on 17 Jul 2017, accepted on 23 Aug 2017 and first published on 30 Aug 2017


Article type: Communication
DOI: 10.1039/C7CY01344B
Citation: Catal. Sci. Technol., 2017, Advance Article
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    One-pot Suzuki–Heck relay to prepare industrially valuable intermediates using the Pd–Cy*Phine catalyst system

    U. K. Das, R. Clément, C. W. Johannes, E. G. Robins, H. Jong and R. T. Baker, Catal. Sci. Technol., 2017, Advance Article , DOI: 10.1039/C7CY01344B

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