A five coordination Cu(ii) cluster-based MOF and its application in the synthesis of pharmaceuticals via sp3 C–H/N–H oxidative coupling

Abstract

Herein, a copper metal–organic framework, termed as VNU-18, containing penta-coordinated sites was successfully synthesized and fully characterized. This material was demonstrated to be an efficient heterogeneous catalyst for the oxidative C–H activation via N–H bonds. The optimized conditions are applicable for the synthesis of pharmaceuticals constructed by α-amino carbonyl skeletons.