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Issue 17, 2017
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Ruthenium-catalyzed oxidative decyanative cross-coupling of acetonitriles with amines in air: a general access to primary to tertiary amides under mild conditions

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Abstract

Catalyzed by Ru and in the presence of air and nucleophiles such as amines or ammonia, activation of the C–CN bond could be easily achieved under mild conditions to produce primary to tertiary amides in good to excellent yields. The use of accessible and functional-group-tolerant starting materials, a cheap, low-loading and recyclable catalyst, ligand-free conditions and excellent product yields are the advantages of the method. Moreover, compared with the Ritter reaction and hydration methods, this novel reaction has more comprehensive application scope.

Graphical abstract: Ruthenium-catalyzed oxidative decyanative cross-coupling of acetonitriles with amines in air: a general access to primary to tertiary amides under mild conditions

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Publication details

The article was received on 18 Apr 2017, accepted on 21 Jul 2017 and first published on 24 Jul 2017


Article type: Paper
DOI: 10.1039/C7CY00761B
Citation: Catal. Sci. Technol., 2017,7, 3747-3757
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    Ruthenium-catalyzed oxidative decyanative cross-coupling of acetonitriles with amines in air: a general access to primary to tertiary amides under mild conditions

    Y. Wang, Z. Wu, Q. Li, B. Zhu and L. Yu, Catal. Sci. Technol., 2017, 7, 3747
    DOI: 10.1039/C7CY00761B

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