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Issue 12, 2017
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An efficient Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in aqueous medium with a zwitterionic ligand, betaine

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Abstract

Cu-catalyzed azide–alkyne cycloaddition reaction in aqueous medium was dramatically accelerated by a simple zwitterionic additive, betaine, at ambient temperature. In the presence of betaine, 1,4-disubstituted-1,2,3-triazoles were obtained from azides and terminal alkynes in excellent yields under 2.5–200 ppm levels of Cu(I) in water. This method resulted in the remarkable reduction of the Cu(I) concentration down to ppm levels. The advantages of this protocol include the use of a conventional Cu catalytic system with commercially available betaine, which is generally non-toxic for biological application. Therefore, this efficient catalytic system should have broad applications in life science research and materials science.

Graphical abstract: An efficient Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in aqueous medium with a zwitterionic ligand, betaine

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Publication details

The article was received on 17 Mar 2017, accepted on 05 Apr 2017 and first published on 26 Apr 2017


Article type: Paper
DOI: 10.1039/C7CY00518K
Citation: Catal. Sci. Technol., 2017,7, 2450-2456
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    An efficient Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in aqueous medium with a zwitterionic ligand, betaine

    J. Shin, S. Oh, H. Lee and Y. Lim, Catal. Sci. Technol., 2017, 7, 2450
    DOI: 10.1039/C7CY00518K

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