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Issue 11, 2017
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DNA-supported palladium nanoparticles as a reusable catalyst for the copper- and ligand-free Sonogashira reaction

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Abstract

DNA nanotechnology has recently emerged as a powerful discipline with diverse applications. However, studies focused on the combination of DNA and metal nanoparticles for catalyst design are scanty. We have prepared a catalyst composed of palladium nanoparticles supported on DNA which has been characterised by TEM, SEM, EDX, UV, FTIR and XPS. The catalyst, mainly composed of Pd(II) and Pd(IV) species in the form of oxides, has been effectual in the copper- and ligand-free Sonogashira–Hagihara coupling of aryl iodides with terminal aromatic and aliphatic alkynes. The products are obtained in 54–86% isolated yields using low catalyst loading (0.5 mol%) under mild conditions (65 °C) in methanol without air exclusion. Moreover, the catalyst can be easily recovered and reused in five cycles and shows better performance than an array of commercial palladium catalysts. The mechanistic aspects of the reaction are also tackled in detail.

Graphical abstract: DNA-supported palladium nanoparticles as a reusable catalyst for the copper- and ligand-free Sonogashira reaction

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Publication details

The article was received on 02 Jan 2017, accepted on 21 Apr 2017 and first published on 24 Apr 2017


Article type: Paper
DOI: 10.1039/C7CY00001D
Citation: Catal. Sci. Technol., 2017,7, 2262-2273
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    DNA-supported palladium nanoparticles as a reusable catalyst for the copper- and ligand-free Sonogashira reaction

    A. S. Camacho, I. Martín-García, C. Contreras-Celedón, L. Chacón-García and F. Alonso, Catal. Sci. Technol., 2017, 7, 2262
    DOI: 10.1039/C7CY00001D

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