Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot

Author affiliations

Abstract

A novel strategy combining visible-light and enzyme catalysis in one pot for the synthesis of 1,3-oxazine derivatives from α- or β-naphthols and ethyl N-aryl glycinates is described for the first time. Various 1,3-oxazine derivatives were prepared with yields of up to 69% under mild reaction conditions by a simple operation. This approach consists of sequential enzymatic hydrolysis and visible-light excited decarboxylation of ethyl N-aryl glycinates, oxidation of α-amino radicals, Mannich reaction, transimination and intramolecular cyclization. This work provides a novel alternative method for the synthesis of 1,3-oxazine derivatives.

Graphical abstract: Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Dec 2016, accepted on 27 Mar 2017 and first published on 28 Mar 2017


Article type: Paper
DOI: 10.1039/C6CY02682F
Citation: Catal. Sci. Technol., 2017,7, 1937-1942
  •   Request permissions

    Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot

    G. Zhang, Y. Xiang, Z. Guan and Y. He, Catal. Sci. Technol., 2017, 7, 1937
    DOI: 10.1039/C6CY02682F

Search articles by author

Spotlight

Advertisements