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Assessing cooperativity in supramolecular systems

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This tutorial review summarises different aspects of cooperativity in supramolecular complexes. We propose a systematic categorisation of cooperativity into cooperative aggregation, intermolecular (allosteric) cooperativity, intramolecular (chelate) cooperativity and interannular cooperativity and discuss approaches to quantify them thermodynamically using cooperativity factors. A brief summary of methods to determine the necessary thermodynamic data is given with emphasis on isothermal titration calorimetry (ITC), a method still underrepresented in supramolecular chemistry, which however offers some advantages over others. Finally, a discussion of very few selected examples, which highlight different aspects to illustrate why such an analysis is useful, rounds up this review.

Graphical abstract: Assessing cooperativity in supramolecular systems

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Publication details

The article was received on 06 Feb 2017 and first published on 29 Mar 2017

Article type: Review Article
DOI: 10.1039/C7CS00063D
Citation: Chem. Soc. Rev., 2017, Advance Article
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    Assessing cooperativity in supramolecular systems

    L. K. S. von Krbek, C. A. Schalley and P. Thordarson, Chem. Soc. Rev., 2017, Advance Article , DOI: 10.1039/C7CS00063D

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