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Issue 16, 2017
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Natural product analogues: towards a blueprint for analogue-focused synthesis

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Abstract

For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.

Graphical abstract: Natural product analogues: towards a blueprint for analogue-focused synthesis

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Publication details

The article was received on 25 Nov 2016 and first published on 04 Jul 2017


Article type: Review Article
DOI: 10.1039/C6CS00842A
Citation: Chem. Soc. Rev., 2017,46, 5059-5109
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    Natural product analogues: towards a blueprint for analogue-focused synthesis

    M. W. P. Bebbington, Chem. Soc. Rev., 2017, 46, 5059
    DOI: 10.1039/C6CS00842A

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