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Issue 6, 2017
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Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

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Abstract

Recent advancement in the area of asymmetric organocatalysis led to the development of new methodologies for the construction of valuable enantiopure molecules, including various heterocycles. As one of the latter class of compounds tetrahydropyrans (THPs) constitute a core structure of a wide array of bioactive natural products. A noticeable growth has been observed in the asymmetric synthesis of THPs using small organic molecules as catalysts. This Tutorial Review describes the organocatalytic methods available to furnish THPs as well as the application of these methodologies in the total synthesis of THP-based natural products.

Graphical abstract: Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

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Publication details

The article was received on 21 Oct 2016 and first published on 06 Mar 2017


Article type: Tutorial Review
DOI: 10.1039/C6CS00757K
Citation: Chem. Soc. Rev., 2017,46, 1661-1674
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    Asymmetric organocatalytic methods for the synthesis of tetrahydropyrans and their application in total synthesis

    F. Vetica, P. Chauhan, S. Dochain and D. Enders, Chem. Soc. Rev., 2017, 46, 1661
    DOI: 10.1039/C6CS00757K

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