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Total synthesis and functional analysis of microbial signalling molecules

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Abstract

Communication is essential for all domains of life. Bacteria use a plethora of small molecules to sense and orchestrate intra- and interspecies communication. Within this review, we will discuss different groups of signalling molecules, including autoinducers, virulence factors and morphogenic substances. On selected examples, we will shortly discuss their ecological roles and biosynthetic proposals. The major part of this review will focus on a systematic overview of the different synthetic methods applied towards the synthesis of signalling molecules and derivatives thereof. The described examples highlight the importance of organic synthetic method development and diversity-oriented total syntheses for structure verification, structure–function analysis and target identification.

Graphical abstract: Total synthesis and functional analysis of microbial signalling molecules

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Publication details

The article was received on 10 May 2017 and first published on 13 Sep 2017


Article type: Review Article
DOI: 10.1039/C6CS00665E
Citation: Chem. Soc. Rev., 2017, Advance Article
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    Total synthesis and functional analysis of microbial signalling molecules

    D. Leichnitz, L. Raguž and C. Beemelmanns, Chem. Soc. Rev., 2017, Advance Article , DOI: 10.1039/C6CS00665E

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