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Issue 6, 2017
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Switchable divergent asymmetric synthesis via organocatalysis

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Abstract

The development of switchable chemo-, regio-, or diastereodivergent reactions, in which two or more structurally and stereogenically different types of chiral products could be produced efficiently from an identical set of starting materials under readily tunable catalytic conditions, is one of the ultimate goals in asymmetric catalysis. This tutorial review will focus on the application of a variety of chiral organic catalysts, including Lewis bases, and Brønsted bases and acids, in a diverse range of stereoselective reactions in a switchable manner. Meanwhile, a few examples of divergent reactions through synergistic activation of organocatalysis and metal catalysis will also be discussed.

Graphical abstract: Switchable divergent asymmetric synthesis via organocatalysis

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Publication details

The article was received on 24 Mar 2016 and first published on 21 Feb 2017


Article type: Tutorial Review
DOI: 10.1039/C6CS00247A
Citation: Chem. Soc. Rev., 2017,46, 1675-1692
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    Switchable divergent asymmetric synthesis via organocatalysis

    G. Zhan, W. Du and Y. Chen, Chem. Soc. Rev., 2017, 46, 1675
    DOI: 10.1039/C6CS00247A

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