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PEG coated vesicles from mixtures of Pluronic P123 and L-α-phosphatidylcholine: Structure, rheology and curcumin encapsulation

Abstract

PEG coated vesicles are important vehicles for the passive targeting of anticancer drugs. With a view to prepare PEG decorated vesicles using co-assembly of block copolymers and lipids, here we investigated the microstructure of aggregates formed in mixtures comprising lipid(L-α-phosphatidylcholine) and block copolymer (Pluronic P123), in the polymer rich regime. DLS and SANS studies show that the structure of the aggregates can be tuned from micelles to rod-like micelles or vesicles by changing the lipid to polymer composition. Rheological studies on gels formed by mixtures of polymer and lipid suggests incorporation of the lipid in the polymer matrix. The encapsulation efficiencies of polymer incorporated liposomes for curcumin and doxorubicin hydrochloride (DOX) are evaluated at different drug to carrier ratio. The pH dependent sustained release of both the drugs from PEGylated liposome suggests its application in development of cost effective formulations for anticancer drug delivery.

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Publication details

The article was received on 04 Aug 2017, accepted on 14 Sep 2017 and first published on 14 Sep 2017


Article type: Paper
DOI: 10.1039/C7CP05303G
Citation: Phys. Chem. Chem. Phys., 2017, Accepted Manuscript
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    PEG coated vesicles from mixtures of Pluronic P123 and L-α-phosphatidylcholine: Structure, rheology and curcumin encapsulation

    B. Dutta, K. C. Barick, G. Verma, V. K. Aswal, I. Freilich, D. Danino, B. G. Singh, I. P. Kavirayani and P. Hassan, Phys. Chem. Chem. Phys., 2017, Accepted Manuscript , DOI: 10.1039/C7CP05303G

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