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Dynamic evolution of vesicle formed by comb-like block copolymers tethered nanoparticles: a dissipative particle dynamics simulation study

Abstract

Vesicles are well-sealed capsules that can store or transport substances. Their dynamic evolution mechanisms are important to fulfill specific functions. In present work, dissipative particle dynamics (DPD) simulation is employed to study the formation, fusion and fission pathways of vesicles. Our results show that comb-like block copolymers tethered nanoparticles can self-assemble into stable vesicle which may be a good candidate for drug entrapment and drug controlled-release. The spontaneous fusion of this type vesicles is studied, whose mechanism is different from vesicles formed of comb-like block copolymers. However, the fission mechanisms of the two type vesicles are similar. To summarize, the introduction of nanoparticles alters the fusion mechanism but makes no difference to the fission way of vesicles. The reason may attribute to the nature of nanoparticles. The fusion and fission always experience the congregation of nanoparticles. The large and rigid nanoparticles inevitably result in the changes of surface tension of vesicle, which is a key factor influencing membrane dynamics.

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Publication details

The article was received on 01 Aug 2017, accepted on 15 Sep 2017 and first published on 15 Sep 2017


Article type: Paper
DOI: 10.1039/C7CP05196D
Citation: Phys. Chem. Chem. Phys., 2017, Accepted Manuscript
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    Dynamic evolution of vesicle formed by comb-like block copolymers tethered nanoparticles: a dissipative particle dynamics simulation study

    Y. Liu, Y. Li and X. Wang, Phys. Chem. Chem. Phys., 2017, Accepted Manuscript , DOI: 10.1039/C7CP05196D

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